Researchers from Fujita Health University have found that chronic hyponatremia (CHN), a condition of prolonged low blood sodium, induces anxiety-like behaviors in mice. CHN disrupts serotonin and dopamine levels and reduces extracellular signal-regulated kinase phosphorylation in the amygdala, a key brain region for emotion. These changes are reversible with sodium level correction. The findings suggest that CHN directly affects brain function and support early diagnosis and treatment to improve mental well-being in affected individuals.

Hyperthermia, a cancer treatment using controlled heat to kill tumor cells, shows promise but faces limitations due to some tumor cells' unexpected heat resistance. Researchers from Japan have now discovered that high cholesterol levels in cancer cell membranes act as a protective barrier, shielding against heat-induced membrane breakdown. When cholesterol was depleted using drugs, previously heat-resistant tumors became vulnerable to hyperthermia treatment, opening new possibilities for personalized cancer therapy targeting cholesterol levels to improve outcomes.

Reading a word involves complex interactions between spelling, meaning, and sound. Researchers from Japan and Canada explore the detailed role of orthographic-semantic consistency—how meaningfully related a word is to its spelling neighbors—in word recognition. By analyzing large datasets and conducting behavioral experiments, the team showed that morphologically-related addition neighbors (e.g., “CREAMY” for “CREAM”) facilitate recognition, while unrelated ones inhibit it. Their findings offer new insights into the cognitive architecture of word recognition. 

A new molecule that lets energy hop around quickly within its structure makes the upcycling of light more efficient and tunable. The Kobe University development lays out a design strategy for better solar power harnessing as well as medical and sensor applications.

A new study reveals striking international differences in how doctors approach the sensitive issue of tracheostomy invasive ventilation (TIV) for patients with amyotrophic lateral sclerosis (ALS). Cultural norms and healthcare systems appear to significantly influence physician attitudes and, consequently, patient choices regarding this life-sustaining treatment.

The Kaiser effect, which is known as a stress memory effect, predicts that seismic events occur only when the previous maximum stress is exceeded. However, the Kaiser effect has only been tested at room temperature in laboratories. Here, we performed deformation experiments on natural olivine at high pressures and high temperatures. We have successfully confirmed a stress memory effect in strongly deformed olivine at high pressures and high temperatures.

Tomoki Matsuzawa (then an undergraduate) and Associate Professor Junji Konuma from Toho University’s Department of Biology conducted the first quantitative study of female earwig forceps. Using morphometric analysis on the maritime earwigs Anisolabis maritima, they found that female forceps also display positive allometry—suggesting that they, too, may have evolved through sexual selection.

To allow studying the genetic causes of autism spectrum disorder, a Kobe University research team created a bank of 63 mouse embryonic stem cell lines containing the mutations most strongly associated with the disorder. The achievement was made possible by developing a new and more efficient method for changing the genome of embryonic stem cells.